Mutagenic effect of radionuclides incorporated into DNA of Drosophila melanogaster. Progress report, 1978-1979
Technical Report
·
OSTI ID:5793645
A significant difference in the mutation frequency of sex-linked recessive lethals was observed due to the position in the DNA molecule in which tritium decay occurred. This local effect of tritium decay is interpreted as being due to the transmutation of tritium to helium-3 at specific sites of tritium incorporation in DNA. The most mutagenic positions of disintegration appear to be the 8 of guanine (adenine) and the 6 of cytosine (thymine), i.e., those beta to the glycosidic bond. No significant increase in temperature sensitive sex-linked recessive lethals was found for tritium decay at the 5-position of cytosine over tritium decay at the other positions tested. Therefore, to determine the mechanism of mutation induction for the different sites of tritium decay, it will be necessary to study mutations induced at a specific locus with an identifiable protein.
- Research Organization:
- Louisiana State Univ., Baton Rouge (USA). Dept. of Zoology and Physiology
- OSTI ID:
- 5793645
- Report Number(s):
- ORO-3728-12
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mutagenic effect of radionuclides incorporated into DNA of Drosophila melanogaster. Progress report, 1975--1976
MUTAGENIC EFFECT OF C 14 AND H 3 LABELLED DNA PRECURSORS INJECTED INTO DROSOPHILA MELANOGASTER MALES
How many loci on the X-chromosome of Drosophila melanogaster can mutate to recessive lethals
Technical Report
·
Wed Dec 31 23:00:00 EST 1975
·
OSTI ID:7344964
MUTAGENIC EFFECT OF C 14 AND H 3 LABELLED DNA PRECURSORS INJECTED INTO DROSOPHILA MELANOGASTER MALES
Journal Article
·
Fri Nov 30 23:00:00 EST 1962
· Canadian Journal of Genetics and Cytology
·
OSTI ID:4728028
How many loci on the X-chromosome of Drosophila melanogaster can mutate to recessive lethals
Journal Article
·
Mon Dec 31 23:00:00 EST 1979
· Environ. Mutagen.; (United States)
·
OSTI ID:5858403
Related Subjects
560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DNA
DROSOPHILA
FLIES
FRUIT FLIES
HYDROGEN ISOTOPES
INSECTS
INVERTEBRATES
ISOTOPES
LIGHT NUCLEI
MUTANTS
MUTATION FREQUENCY
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
TRITIUM
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DNA
DROSOPHILA
FLIES
FRUIT FLIES
HYDROGEN ISOTOPES
INSECTS
INVERTEBRATES
ISOTOPES
LIGHT NUCLEI
MUTANTS
MUTATION FREQUENCY
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
TRITIUM
YEARS LIVING RADIOISOTOPES