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Tritium and other radionuclide labeled organic compounds incorporated in genetic material

Book ·
OSTI ID:5793036
Incorporation of tritiated thymidine into DNA introduces complications which make the values of maximum permissible concentration given by NCRP inappropriate. This problem is discussed in this report. The incorporation of labelled nucleic acid precursors into the nucleus of the hematopoietic stem cell leads to cell nuclei which are exposed to much higher doses of radiation than the adjacent cytoplasm. The labelled precursors are incorporated into the nucleus when DNA and RNA are synthesized. Nucleated cells synthesize RNA almost continually, whereas DNA synthesis at a time period between 2 cell divisions. About 10% of the hematopoietic stem cells are undergoing DNA synthesis at any one time and incorporating specific precursors (thymidine). If the degree of labelling is known, the dose to the stem cells can be calculated. The objective in this report was to keep the average radiation dose below 5 rem per annum. The nuclear volume was determined. Amounts of labelled nucleic acid precursors administered one time or continuously that would deliver 5 rem per year to the stem cell were calculated. The results are included in the article. (DC)
Research Organization:
National Council on Radiation Protection and Measurements, Washington, DC
OSTI ID:
5793036
Report Number(s):
NCRP-63
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CELL CONSTITUENTS
CELL DIVISION
CELL NUCLEI
DNA
HAZARDS
HEALTH HAZARDS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAXIMUM PERMISSIBLE CONCENTRATION
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRECURSOR
PYRIMIDINES
RADIATION EFFECTS
RADIOISOTOPES
RIBOSIDES
RNA
SAFETY STANDARDS
SOMATIC CELLS
STANDARDS
STEM CELLS
SYNTHESIS
THYMIDINE
TRITIUM
YEARS LIVING RADIOISOTOPES