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Effect of trihydroxyoctadecadienoic acids on blood levels of prostaglandins E/sub 2/ and F/sub 2. cap alpha. / and of 5-hydroxyeicosatetraenoic acid in rats with alloxan diabetes

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
DOI:https://doi.org/10.1007/BF00834405· OSTI ID:5779676
; ; ;
The effect of the trihydroxyoctadecadienoic acids (THODA) fraction on blood levels of some eicosanoids and, in particular, of prostaglandins E/sub 2/ and F/sub 2..cap alpha../(PGE/sub 2/ and PGF/sub 2..cap alpha../), and 5-hydroxyeicosatetraenoic acid (5-HETE) in rats with alloxan diabetes was studied. Concentrations of PGE/sub 2/, PGF/sub 2..cap alpha../, and 5-HETE in peripheral blood plasma were determined by radioimmunoassay. To assess the loss of substances during extraction and chromatography, /sup 3/H/sub 8/-PGE/sub 2/, /sup 3/H/sub 8/-PGF/sub 2..cap alpha.., and /sup 3/H/sub 8/-5-HETE were used. Plasma PGE/sub 2/, PGF/sub 2..cap alpha../, and 5-HETE levels in albino rats with alloxan diabetes and after injection of THODA are shown.
Research Organization:
Institute of Biochemistry, Erevan, USSR
OSTI ID:
5779676
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:4; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ALLOXAN
ANIMALS
AZINES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CHEMISTRY
COUNTING TECHNIQUES
DECANOIC ACID
DIABETES MELLITUS
DISEASES
EICOSANOIC ACID
ENDOCRINE DISEASES
GLUCOSE
HETEROCYCLIC COMPOUNDS
HEXOSES
IMMUNOASSAY
IMMUNOLOGY
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLIC DISEASES
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PROSTAGLANDINS
PYRIMIDINES
QUANTITY RATIO
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RATS
RODENTS
SACCHARIDES
SCINTILLATION COUNTING
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES