Pathogenesis of normal-pressure hydrocephalus--preliminary observations

Journal Article · Fri Feb 01 04:00:00 EST 1985 · Surg. Neurol. (Tryon, N.C.); (United States)

DOI:https://doi.org/10.1016/0090-3019(85)90329-5· OSTI ID:5777415

Meyer, J S; Kitagawa, Y; Tanahashi, N; Tachibana, H; Kandula, P; Cech, D A; Rose, J E; Grossman, R G

Eight cases with well-documented normal-pressure hydrocephalus were studied prospectively for 6 months by history, neurological examinations, Mini-Mental Status tests, xenon-contrast computed tomography measurements of local cerebral blood flow, and cerebral xenon solubility expressed as partition coefficients. Local cerebral blood flow and local partition coefficients were reduced throughout frontal and temporal lobes, basal ganglia, and thalamus. Cerebrospinal fluid shunting procedures were carried out in seven cases. As a result, local cerebral blood flow and local partition coefficients increased toward normal, particularly in frontal white matter, frontotemporal cortex, and basal ganglia. Ventricular size became reduced and mental status improved. Local partition coefficient values were reduced by increased tissue water because low values confirmed cerebrospinal fluid diffusion into white matter, which resolved after shunting. Patients likely to benefit from shunting, including shunt failures requiring revision, were detected.

• Research Organization: Baylor Coll. of Medicine, Houston, TX
• OSTI ID: 5777415
• Journal Information: Surg. Neurol. (Tryon, N.C.); (United States), Journal Name: Surg. Neurol. (Tryon, N.C.); (United States) Vol. 23:2; ISSN SGNRA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MATERIALS
BLOOD FLOW
BODY
BODY FLUIDS
BRAIN
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
COMPUTERIZED TOMOGRAPHY
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DISEASES
ISOTOPES
MATERIALS
NERVOUS SYSTEM
ORGANS
PATHOGENESIS
PATIENTS
TOMOGRAPHY
XENON ISOTOPES