Brain Ia antigens have a bone marrow origin
Journal Article
·
· Immunogenetics (N.Y.); (United States)
Our results, using radiation-induced bone marrow chimeras, demonstrate that the Ia antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of Ia in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.
- Research Organization:
- Department of Microbiology, University of Southern California, School of Medicine, Los Angeles
- OSTI ID:
- 5776075
- Journal Information:
- Immunogenetics (N.Y.); (United States), Journal Name: Immunogenetics (N.Y.); (United States) Vol. 17:3; ISSN IMNGB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BODY
BONE MARROW CELLS
BRAIN
CENTRAL NERVOUS SYSTEM
CHIMERAS
CONNECTIVE TISSUE CELLS
GLOBULINS
IMMUNOGLOBULINS
MOSAICISM
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PRECURSOR
PROTEINS
RADIATION CHIMERAS
SOMATIC CELLS
STEM CELLS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BODY
BONE MARROW CELLS
BRAIN
CENTRAL NERVOUS SYSTEM
CHIMERAS
CONNECTIVE TISSUE CELLS
GLOBULINS
IMMUNOGLOBULINS
MOSAICISM
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PRECURSOR
PROTEINS
RADIATION CHIMERAS
SOMATIC CELLS
STEM CELLS