Evaluation of the Ca sup 2 sup + distribution in aortic tissue of spontaneously hypertensive and normotensive rats

Journal Article · Fri Feb 01 04:00:00 EST 1991 · American Journal of Hypertension; (USA)

DOI:https://doi.org/10.1093/ajh/4.2.192· OSTI ID:5768560

Spieker, C; Zidek, W; von Bassewitz, D B; Heck, D; Rahn, K H

In the present study, particle-induced X-ray emission (PIXE) was used to get information on the spatial distribution of Ca{sup 2}{sup +} in aortas of spontaneously hypertensive rats (SHR) and normotensive controls aged 1 week, 4 weeks, and 12 weeks. To differentiate changes in Ca{sup 2}{sup +} metabolism in hypertensive arteries from secondary phenomena due to the arteriosclerosis, the animals were examined in the earliest stage of hypertension. It was found that the Ca{sup 2}{sup +} content was not elevated in the aortic smooth muscle of SHR aged 1 week (n = 11), as compared to normotensive controls (n = 10) (186.8 +/- 89.9 micrograms Ca{sup 2}{sup +}/g tissue v 254.0 +/- 173.3 micrograms Ca{sup 2}{sup +}/g). The Ca{sup 2}{sup +} content was raised (P less than .05) in the aortic smooth muscle of SHR aged 4 weeks (n = 13), as compared to 12 WKY rats (4 weeks) (726.0 +/- 130.4 micrograms Ca{sup 2}{sup +}/g tissue v 440.3 +/- 214.4 micrograms Ca{sup 2}{sup +}/g) and in 17 SHR (3 months), as compared to 13 WKY rats, respectively (3390.1 +/- 729.9 micrograms Ca{sup 2}{sup +}/g tissue v 1632.1 +/- 569.5 micrograms Ca{sup 2}{sup +}/g). The results confirm the age-related increase in the arterial Ca{sup 2}{sup +} content in normotensive rats and demonstrate additionally that this age-related rise in arterial Ca{sup 2}{sup +} content is accelerated in SHR.

• OSTI ID: 5768560
• Journal Information: American Journal of Hypertension; (USA), Journal Name: American Journal of Hypertension; (USA) Vol. 4:2 Pt 1; ISSN AJHYE; ISSN 0895-7061
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
AORTA
ARTERIES
BLOOD VESSELS
BODY
CALCIUM COMPOUNDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
DIAGNOSIS
DISEASES
DISTRIBUTION
HYPERTENSION
MAMMALS
NONDESTRUCTIVE ANALYSIS
ORGANS
RATS
RODENTS
SYMPTOMS
TISSUE DISTRIBUTION
VASCULAR DISEASES
VERTEBRATES
X-RAY EMISSION ANALYSIS