The time course of steroid action on blood-to-brain and blood-to-tumor transport of 82Rb: A positron emission tomographic study

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410250306· OSTI ID:5766997

Jarden, J O; Dhawan, V; Moeller, J R; Strother, S C; Rottenberg, D A

Blood-to-brain and blood-to-tumor transport rate constants for Rb (K1) and apparent tissue blood volume (Vb) were estimated in 8 patients with primary or metastatic brain tumors before and approximately 6 hours after a 100-mg intravenous bolus injection of dexamethasone using /sup 82/Rb and positron emission tomography. Eight additional patients were studied to evaluate test-retest variability and repositioning errors. Six hours following dexamethasone administration tumor K1 (but not Vb) was significantly reduced compared with contralateral control brain regions (p less than 0.03). These data are consistent with our previously published 24-hour-postdexamethasone data and suggest that comparable effects of corticosteroids on brain/tumor capillaries may be observed at 5 to 6 and 24 hours. The time course of dexamethasone-induced alterations in brain/tumor capillary permeability supports the view that these alterations may be responsible for at least some of the antiedema effects of corticosteroids.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY (USA)
• OSTI ID: 5766997
• Journal Information: Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 25:3; ISSN ANNED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
CORTICOSTEROIDS
DEXAMETHASONE
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GLUCOCORTICOIDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KETONES
METASTASES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PERMEABILITY
POSITRON COMPUTED TOMOGRAPHY
PREGNANES
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM ISOTOPES
STEROIDS
TOMOGRAPHY