Stereotyped distribution of proliferating keratinocytes in disorders affecting the epidermis
Journal Article
·
· Am. J. Dermatopathol.; (United States)
We used the technique of autoradiography after incorporation of tritiated thymidine (/sup 3/H-TdR) to evaluate keratinocyte proliferation in basal, epibasal, and other epidermal layers in 30 diseases affecting the epidermis. The number and proportion of /sup 3/H-TdR-labeled keratinocytes were counted in the different layers of the epidermis. Significant correlations were found between the proliferative indices of the different epidermal layers. Such links indicate that the epidermis responds in a rather stereotyped way to various pathological conditions. There exists some regulation in the distribution, number, and proportion of /sup 3/H-TdR-labeled keratinocytes in the various layers of the epidermis.
- Research Organization:
- Univ. of Liege (Belgium)
- OSTI ID:
- 5765932
- Journal Information:
- Am. J. Dermatopathol.; (United States), Journal Name: Am. J. Dermatopathol.; (United States) Vol. 11:3; ISSN AJODD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
AZINES
BODY
CELL PROLIFERATION
DISEASES
EPIDERMIS
EPITHELIUM
HETEROCYCLIC COMPOUNDS
KERATIN
LABELLED COMPOUNDS
MAMMALS
MAN
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PRIMATES
PROTEINS
PYRIMIDINES
RIBOSIDES
SCLEROPROTEINS
SKIN
SKIN DISEASES
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
AZINES
BODY
CELL PROLIFERATION
DISEASES
EPIDERMIS
EPITHELIUM
HETEROCYCLIC COMPOUNDS
KERATIN
LABELLED COMPOUNDS
MAMMALS
MAN
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PRIMATES
PROTEINS
PYRIMIDINES
RIBOSIDES
SCLEROPROTEINS
SKIN
SKIN DISEASES
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
VERTEBRATES