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Quantitative angiography of the left anterior descending coronary artery: correlations with pressure gradient and results of exercise thallium scintigraphy

Journal Article · · Circulation; (United States)
; ; ; ; ; ; ;

To evaluate, during cardiac catheterization, what constitutes a physiologically significant obstruction to blood flow in the human coronary system, computer-based quantitative analysis of coronary angiograms was performed on the angiograms of 31 patients with isolated disease of the proximal left anterior descending coronary artery. The angiographic severity of stenosis was compared with the transstenotic pressure gradient measured with the dilation catheter during angioplasty and with the results of exercise thallium scintigraphy. A curvilinear relationship was found between the pressure gradient across the stenosis (normalized for the mean aortic pressure) and the residual minimal area of obstruction (after subtracting the area of the angioplasty catheter). This relationship was best fitted by the equation: normalized mean pressure gradient . a + b . log (obstruction area), r . .74. The measurements of the percent area of stenosis (cutoff 80%) and of the transstenotic pressure gradient (cutoff 0.30) obtained at rest correctly predicted the occurrence of thallium perfusion defects induced by exercise in 83% of the patients.

Research Organization:
Erasmus Univ., Rotterdam, Netherlands
OSTI ID:
5765727
Journal Information:
Circulation; (United States), Journal Name: Circulation; (United States) Vol. 71:2; ISSN CIRCA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BIOMEDICAL RADIOGRAPHY
BLOOD CIRCULATION
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERS
CORONARIES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
EQUATIONS
EXERCISE
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATIENTS
PERFUSED ORGANS
PRESSURE GRADIENTS
RADIOISOTOPE SCANNING
RADIOLOGY
SCINTISCANNING
THALLIUM ISOTOPES