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Influence of the location of left anterior descending coronary artery stenosis on left ventricular function during exercise

Journal Article · · Circulation; (United States)
;

The purpose of this investigation was to determine if a stenosis of a coronary artery located proximally caused greater deterioration of left ventricular function than a stenosis of a similar magnitude located more distally in the artery. Twenty-six patients with isolated left anterior descending coronary artery (LAD) lesions documented by cardiac catheterization were studied by radionuclide angiocardiography (RNA) at rest and during exercise on a bicycle ergometer. Thirteen patients (nine males and four females) had a proximal lesion of the LAD averaging 9.1 +/- 11% of the diameter of the lumen (group 1) and 13 patients (eight males and five females) had a distal lesion averaging 88 +/- 12% of the lumen (group 2). The mean age of group 1 was 49 +/- 9 years and the mean age of group 2 was 48 +/- 9 years. The findings indicate that a stenotic lesion located at a more proximal level of the coronary arterial system reduces blood flow in a larger area of myocardium, resulting in a more pronounced ischemic response to exercise than a similar lesion located more distally.

Research Organization:
Duke Univ. Medical Center, Durham, NC
OSTI ID:
5586613
Journal Information:
Circulation; (United States), Journal Name: Circulation; (United States) Vol. 65:1; ISSN CIRCA
Country of Publication:
United States
Language:
English

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Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EXERCISE
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES