Low capacity of erythrocytes to bind with immune complexes via C3b receptor in patients with systemic lupus erythematosus: correlation with pathological proteinuria

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Clin. Immunol. Immunopathol.; (United States)

DOI:https://doi.org/10.1016/0090-1229(85)90013-3· OSTI ID:5764028

Nojima, Y; Terai, C; Minota, S; Takano, K; Miyakawa, Y; Takaku, F

Erythrocytes from 51 patients with systemic lupus erythematosus and 75 controls were tested for the capacity to bind aggregated human gamma-globulin labeled with radioiodine in the presence of complement. Both in patients and controls, a trimodal distribution of binding capacity was observed. Low (less than 9% of the added radioactivity), intermediate (9-17%), and high binding (more than 17%) were observed in 13, 58, and 29% in controls and in 49, 43 and 8% in lupus patients. The low binding capacity of erythrocytes persisted even after patients entered remission following steroid therapy. A genetic control of binding capacity was supported by familial surveys. Prevalence of pathological proteinuria was significantly higher in patients with low binding capacity than those with intermediate or high binding capacity (16/25 vs 7/26, P less than 0.01). These results indicate that an impaired physiological disposal of immune complexes via the erythrocyte C3b receptor in lupus patients may contribute to the development of renal involvement.

• Research Organization: Univ. of Tokyo, Japan
• OSTI ID: 5764028
• Journal Information: Clin. Immunol. Immunopathol.; (United States), Vol. 34:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ERYTHROCYTES
CHEMICAL BONDS
RECEPTORS
ANTIGEN-ANTIBODY REACTIONS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
GENETIC CONTROL
GLOBULINS-GAMMA
IMMUNITY
IMMUNOGLOBULINS
IODINE ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LUPUS
PATIENTS
STEROIDS
TRACER TECHNIQUES
UROGENITAL SYSTEM DISEASES
BACTERIAL DISEASES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONTROL
DISEASES
GLOBULINS
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PEST CONTROL
PROTEINS
SKIN DISEASES
THERAPY
TUBERCULOSIS
550901* - Pathology- Tracer Techniques