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Comparative survival of clonogenic cells of a murine epithelioma irradiated in vivo with 250 kVp x rays, /sup 60/Co gamma rays, or negative pions produced by the cyclotron at TRIUMF

Journal Article · · Radiology; (United States)
OSTI ID:5761273
Squamous carcinomas in WHT/Ht mice were exposed to the biomedical pion beam at TRIUMF. The biological effects of the pion beam were compared to those of 250 kVp x rays. The dose rates were 2 to 3 rad/min (.02 to .03 Gy/min) for pions and 56 rad/min (.56 Gy) for x rays. The surviving fraction of epithelioma cells irradiated in vivo was studied using the TD50 assay. RBE values for pions were calculated from the ratio of the x-ray and pion D/sub 0/ values and were found to be 1.6 +- 0.3 for oxic cells and 2.1 +- 0.4 for hypoxic cells. OER values were 1.8 +- 0.5 for pions and 2.4 +- 0.4 for 250 kVp x rays.
Research Organization:
Univ. of Tokyo, Japan
OSTI ID:
5761273
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 133:2; ISSN RADLA
Country of Publication:
United States
Language:
English

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