A role for magnesium in neonatal parathyroid gland function

Journal Article · Mon Apr 01 04:00:00 EST 1991 · Journal of the American College of Nutrition; (USA)

DOI:https://doi.org/10.1080/07315724.1991.10718135· OSTI ID:5760969

Loughead, J L; Mimouni, F; Tsang, R C; Khoury, J C ^[1]

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1. Univ. of Cincinnati College of Medicine, OH (USA)

Little is known of the factors regulating parathyroid function in the neonatal period. Twenty-seven term infants born after uncomplicated pregnancies, labors, and deliveries were studied to test the hypothesis that in normal newborns the amplitude of parathyroid hormone (PTH) response to decreasing serum ionized calcium (iCa) correlates with serum magnesium (Mg) concentrations. Serum iCa (ion selective electrode, Radiometer ICA 1), PTH (1-84 intact molecules, radioimmunoassay) and Mg (atomic absorption) were measured at birth (cord blood) and 24 hours of age. Repeated measures analysis of covariance showed decreasing serum iCa (p less than 0.01) and increasing serum Mg (p less than 0.01) and PTH (p less than 0.01) over time. The change in PTH over the first 24 hours was directly correlated with cord blood (r = 0.38, p less than 0.05) and 24-hr Mg concentrations (r = 0.53, p less than 0.01). We conclude that the ability of the parathyroid gland to respond to decreasing serum iCa after birth is directly related to Mg status. We speculate that neonatal hypomagnesemia may lead to a blunted PTH secretory response, thus contributing to early neonatal hypocalcemia.

• OSTI ID: 5760969
• Journal Information: Journal of the American College of Nutrition; (USA), Journal Name: Journal of the American College of Nutrition; (USA) Vol. 10:2; ISSN 0731-5724; ISSN JONUD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION SPECTRA
AGE GROUPS
ALKALINE EARTH METALS
BIOASSAY
BIOLOGICAL FUNCTIONS
BIOSYNTHESIS
BODY
CALCIUM
CHILDREN
DIAGNOSTIC TECHNIQUES
ELEMENTS
ENDOCRINE GLANDS
GLANDS
HORMONES
IMMUNOASSAY
IMMUNOLOGY
INFANTS
ISOTOPE APPLICATIONS
MAGNESIUM
MATHEMATICS
METABOLISM
METALS
ORGANIC COMPOUNDS
ORGANS
PARATHORMONE
PARATHYROID GLANDS
PEPTIDE HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
REGRESSION ANALYSIS
SPECTRA
STATISTICS
SYNTHESIS
TRACER TECHNIQUES