Parathyroid hormone effects on skeletal exchangeable calcium and bone blood flow

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:6975159

Brindley, G W; Williams, E A; Bronk, J T; Meadows, T H; Montgomery, R J; Smith, S R; Kelly, P J ^[1]

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1. Mayo Clinic and Mayo Foundation, Rochester, MN (USA)

The effects of alterations in serum calcium levels on the volume of distribution of a calcium tracer in bone and on bone blood flow were investigated in dogs by manipulation of parathyroid status. The volume of distribution increases with increasing serum calcium. This implies that there is a concentration-dependent binding mechanism in the extravascular space of bone, which is not saturated at the levels of serum calcium achieved in these experiments. The skeletal exchangeable calcium was increased in hypercalcemic dogs and decreased in hypoclacemic dogs. Cancellous bone contains proportionately more exchangeable calcium than cortical bone. Bone blood flow was decreased by 50% 15 min after injection of a bolus of parathyroid hormone (PTH) but returned to control values by 240 min. Fifty-two hours after the induction of hypercalcemia with repeated doses of PTH, there was no difference in blood flow over control animals.

• OSTI ID: 6975159
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:1; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD FLOW
BODY
BODY FLUIDS
BONE TISSUES
CALCIUM 45
CALCIUM ISOTOPES
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HORMONES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
METABOLIC DISEASES
METABOLISM
NUCLEI
ORGANS
PARATHORMONE
PEPTIDE HORMONES
RADIOISOTOPES
RADIONUCLIDE KINETICS
SKELETON
STRONTIUM 85
STRONTIUM ISOTOPES
TISSUES
URINE
VERTEBRATES
WASTES