The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes
- Department of Microbiology, Mount Sinai School of Medicine, New York, NY (United States)
The erythrocyte delta-aminolevulinate dehydratase (ALAD) isozyme phenotypes and the blood lead levels were determined in a population of 202 lead factory workers in Germany and an environmentally exposed population of 1278 children in New York who had elevated free protoporphyrin levels. In both population, individuals with the ALAD 1-2 or 2-2 isozyme phenotype had levels of blood lead statistically higher than those individuals with the ALAD 1-1 isozyme phenotype (lead workers: P greater than 0.004; children: P greater than 0.0001). Homozygotes and heterozygotes for the ALAD2 allele who expressed the 2-2 or 1-2 isozyme phenotype had median blood lead levels that were about 9 to 11 micrograms/dl greater than similarly exposed individuals who were homozygous for the ALAD1 allele. These findings support the hypothesis that the ALAD2 polypeptide binds lead more effectively, and therefore that individuals with the ALAD2 allele may be more susceptible to lead poisoning.
- OSTI ID:
- 5752145
- Journal Information:
- Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 56:2; ISSN 0013-9351; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMALS
BIOSYNTHESIS
CARBON-OXYGEN LYASES
CARBOXYLIC ACIDS
CHILDREN
DEVELOPED COUNTRIES
ELEMENTS
ENVIRONMENTAL EXPOSURE
ENZYMES
FEDERAL REGION II
GERMANY
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ISOENZYMES
LEAD
LYASES
MAMMALS
MAN
METABOLISM
METALLURGY
METALS
NEW YORK
NEW YORK CITY
NORTH AMERICA
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PERSONNEL
PHENOTYPE
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
PROTOPORPHYRINS
SYNTHESIS
TOXICITY
URBAN AREAS
USA
VERTEBRATES