Blood flow in exercising muscles by xenon clearance and by microsphere trapping

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States)

OSTI ID:5751884

Cerretelli, P; Marconi, C; Pendergast, D; Meyer, M; Heisler, N; Piiper, J

The accuracy of muscle blood flow measurement by the /sup 133/Xe clearance method (Qxe) was assessed against direct venous outflow (Qv) and microsphere trapping flow (Q..mu..) determinations in isolated perfused dog gastrocnemius both at rest and during graded stimulation (O/sub 2/ consumption (Vo/sub 2/) up to 12 ml x 100 g/sup -1/ x min/sup -1/) and in the gastrocnemius, vastus lateralis, and triceps of intact dogs at rest and while running on a treadmill at varied speeds up to maximum Vo/sub 2/. In 29 measurements performed in 11 isolated muscles, Q..mu.. was in good agreement with Qv at rest and at all stimulation levels (Q..mu../Qv = 1.0 r = 0.98). /sup 133/Xe clearance yielded much lower blood flows than the venous outflow and the microsphere trapping methods. In 43 measurements in 11 muscles, the mean Qxe/Qv ratio was 0.57 +/- 0.03 (SE), independent of blood flow. Similarly, in 65 measurements in 2 intact dogs, the mean Qxe/Q..mu.. ratio in all tested muscles was 0.49 +/- 0.02 (SE), independent of blood flow. These results show that the /sup 133/Xe clearance method considerably underestimates blood flow in dog muscles.

• Research Organization: Max-Planck-Institut fuer Experimentelle Medizin, Goettingen, West Germany
• OSTI ID: 5751884
• Journal Information: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States), Journal Name: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States) Vol. 56:1; ISSN JARPD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD-PLASMA CLEARANCE
BODY
CLEARANCE
DAYS LIVING RADIOISOTOPES
DOGS
ELEMENTS
EVEN-ODD NUCLEI
EXERCISE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MUSCLES
NONMETALS
NUCLEI
ORGANS
OXYGEN
PERFUSED ORGANS
QUANTITY RATIO
RADIOISOTOPES
UPTAKE
VERTEBRATES
XENON 133
XENON ISOTOPES