Effects of cortisone on liver blood flow in experimental hemorrhagic shock: using a new simplified radioisotope clearance method to measure liver blood flow. [Dogs, /sup 133/Xe]

Journal Article · Thu Jun 01 04:00:00 EDT 1978 · J. Trauma; (United States)

OSTI ID:5612219

Guelgoenen, A; Ercan, M T

Liver blood flow was measured in the dog under control and hemorrhagic shock conditions by the /sup 133/Xe clearance method. /sup 133/Xe was administered first into the portal vein and its clearance from the liver recorded, and then directly into the liver tissue and another clearance curve was obtained. The results were compared. We have also investigated the effects of corticosteroids, given in pharmacologic doses, on liver blood flow in hemorrhagic shock. We have shown that the difference between the results of tissue injection and those of portal injection of /sup 133/Xe was not significant (p greater than 1.10). Hemodynamic studies indicated that the liver blood flow is decreased, the liver venous resistance and portal venous pressures are increased in dogs in hemorrhagic shock, and that hydrocortisone, with the blood pressure and the bleedout volume held constant in the experimental model, lowers the liver venous resistance and raises the liver blood flow significantly (p less than 0.05) at various stages of hemorrhagic shock.

• Research Organization: Hacettepe Univ., Ankara, Turkey
• OSTI ID: 5612219
• Journal Information: J. Trauma; (United States), Journal Name: J. Trauma; (United States) Vol. 18:6; ISSN JOTRA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL SHOCK
BLOOD FLOW
BLOOD-PLASMA CLEARANCE
BODY
CLEARANCE
CORTICOSTEROIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOGS
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
GLANDS
HEMORRHAGE
HORMONES
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LIVER
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
STEROID HORMONES
STEROIDS
SYMPTOMS
VERTEBRATES
XENON 133
XENON ISOTOPES