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Graves disease with ophthalmopathy following radiotherapy for Hodgkin's disease

Journal Article · · Am. J. Med. Sci.; (United States)
;
The number of patients achieving long-term survival following neck irradiation for Hodgkin's disease and other malignancies is increasing. Paralleling this increase in survivors is the development of late complications of the therapy itself. Eleven patients have previously been reported who developed Graves ophthalmopathy 18 months to seven years after receiving neck radiotherapy for nonthyroidal malignancies. The seven patients who had HLA typing were all HLA-B8 negative, despite the reported association of the HLA-B8 antigen with Graves disease. A patient who is HLA-B8 positive who developed Graves ophthalmopathy and hyperthyroidism nine years after receiving mantle radiotherapy for Hodgkin's disease is reported. It is recommended that Graves disease be included among the thyroid diseases that receive consideration during follow-up of patients who have received mantle radiotherapy.
Research Organization:
Cleveland Veterans Administration Medical Center, OH
OSTI ID:
5749295
Journal Information:
Am. J. Med. Sci.; (United States), Journal Name: Am. J. Med. Sci.; (United States) Vol. 288:5; ISSN AJMSA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DELAYED RADIATION EFFECTS
DISEASES
ENDOCRINE DISEASES
HODGKINS DISEASE
HYPERTHYROIDISM
INJURIES
LYMPHOMAS
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECOMMENDATIONS
SENSE ORGANS DISEASES
SIDE EFFECTS
SURVIVAL TIME
THERAPY