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Acute toxicity and preliminary therapeutic results of pelvic lymphadenectomy combined with transperineal interstitial implantation of /sup 192/IR and external beam radiotherapy for locally advanced prostate cancer

Journal Article · · Urology (Ridgewood, N.J.); (United States)
; ; ; ; ;
A combined modality approach has been developed for treatment of locally advanced prostate cancer consisting of: surgical staging with lymphadenectomy; transperineal placement of afterloading needles for a course of /sup 192/Ir brachytherapy; and a course of moderate-dose external beam irradiation to tight prostatic fields. The flexibility of the treatment permits adaptation of the dose to any tumor configuration. A total of 23 patients have been treated to date; 18 are available for treatment review and 14 for acute toxicity analysis. Significant morbidity has occurred in only 2 patients, 1 with a pelvic hematoma and 1 with hematoma in the wound. Local tumor response has been excellent in all but 1 patient. A good degree of symptomatic improvement was observed at the three-month follow-up. This approach appears to be safe and effective at this time. A brief review of the technique and the rationale for its use are also presented.
Research Organization:
Mayo Clinic, Rochester, MN
OSTI ID:
5748879
Journal Information:
Urology (Ridgewood, N.J.); (United States), Journal Name: Urology (Ridgewood, N.J.); (United States) Vol. 25:3; ISSN URGYA
Country of Publication:
United States
Language:
English

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