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The effects of preoperative radiation on healing of rat colonic anastomoses

Journal Article · · Dis. Colon Rectum; (United States)
DOI:https://doi.org/10.1007/BF02552971· OSTI ID:5744274
; ;
The effect of delaying surgery, after a nominal standard dose of 4500 rad was administered to the abdomen of rats, on the healing of colonic anastomoses was evaluated. Healing, as determined by bursting pressure of colonic segments, was significantly depressed (p less than 0.05) at five days after surgery in groups irradiated five or 15 days prior to surgery as compared with groups receiving either no radiotherapy or irradiation ten days prior to surgery. Five-day healing was not significantly depressed in the group irradiated ten days prior to operation as compared with the group receiving no irradiation. No significant (p less than 0.05) differences were noted at ten or 15 days after surgery between groups that were and were not irradiated. At ten days after surgery all groups had higher bursting pressures than the control group at five days after surgery. Thus, there appears to be an optimal time interval between radiation and surgery to ensure maximal colonic healing.
Research Organization:
Department of Surgery, University of Arkansas for Medical Sciences, Little Rock
OSTI ID:
5744274
Journal Information:
Dis. Colon Rectum; (United States), Journal Name: Dis. Colon Rectum; (United States) Vol. 26:9; ISSN DICRA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
HEALING
INJURIES
INTESTINES
LARGE INTESTINE
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RATS
RECOVERY
RECTUM
RODENTS
SURGERY
THERAPY
TIME DEPENDENCE
VERTEBRATES
WOUNDS