Effect of supplemental vitamin A on colon anastomotic healing in rats given preoperative irradiation
Journal Article
·
· Am. J. Surg.; (United States)
We studied the effect of dietary supplementation with vitamin A on the healing of colon anastomoses in irradiated bowel. Rats were divided into two groups. Those in the first group were fed a standard chow diet and those in the second group were fed the same diet supplemented with 150 IU vitamin A/g of chow. The rats were maintained on their respective diets throughout the experiment. After 7 days, half the rats in each group underwent abdominal irradiation (200 rads). Seven days later, all of the rats underwent distal colon division and anastomosis under pentobarbital anesthesia. All rats were killed 7 days postoperatively, the colons excised, and bursting strength and hydroxyproline determinations performed on both the anastomotic segment and a normal proximal segment of adjacent colon. There was a significant decrease in the bursting strength at the colon anastomosis (p less than 0.02) and in the collagen content (p less than 0.02) after preoperative irradiation. This effect was mitigated by dietary vitamin A supplementation.
- Research Organization:
- Albert Einstein College of Medicine, Bronx, NY
- OSTI ID:
- 6700280
- Journal Information:
- Am. J. Surg.; (United States), Journal Name: Am. J. Surg.; (United States) Vol. 2; ISSN AJSUA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of irradiation on healing of newly made colonic anastomoses in the rat
Effect of preoperative irradiation on healing of low colorectal anastomoses
Experience with the biofragmentable anastomotic ring (BAR) in bowel preoperatively irradiated with 6000 rad
Journal Article
·
Tue Nov 30 23:00:00 EST 1993
· International Journal of Radiation Oncology, Biology and Physics; (United States)
·
OSTI ID:6568840
Effect of preoperative irradiation on healing of low colorectal anastomoses
Journal Article
·
Tue Jan 31 23:00:00 EST 1984
· Am. J. Surg.; (United States)
·
OSTI ID:7013145
Experience with the biofragmentable anastomotic ring (BAR) in bowel preoperatively irradiated with 6000 rad
Journal Article
·
Wed Feb 28 23:00:00 EST 1990
· Diseases of the Colon and Rectum; (USA)
·
OSTI ID:7136465
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COLLAGEN
DIET
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
INTESTINES
LARGE INTESTINE
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RADIATION PROTECTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RATS
RODENTS
SCLEROPROTEINS
SIDE EFFECTS
SURGERY
THERAPY
VERTEBRATES
VITAMIN A
VITAMINS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COLLAGEN
DIET
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
INTESTINES
LARGE INTESTINE
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RADIATION PROTECTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RATS
RODENTS
SCLEROPROTEINS
SIDE EFFECTS
SURGERY
THERAPY
VERTEBRATES
VITAMIN A
VITAMINS