1982 Resident's Essay Award: the immunologic effects of lymphoid irradiation in human and non-human primates: cellular changes and the potential for renal transplantation
Previous reports have suggested that the immunosuppressive effects of lymphoid irradiation (LI) are related to changes in T cell peripheral blood levels. We prospectively studied 13 patients with Stages I and II Hodgkin's disease before, during, and after a course of LI. Forty to 45Gy delivered to the mantle field in 4-1/2 to 5 weeks was followed by a 3 to 4 week break and 35 to 40 Gy to the paraaortic field. The absolute lymphocyte count prior to LI was 1400 +- 270/mm3. This fell to 597 +- 280/mm3 at the conclusion of LI and returned to 1490 +- 800/mm3 at 7 to 8 months post-LI. Seven previously spleenectomized cynomolgus monkeys received 20Gy of LI in 20 equal daily fractions over a 4 week period through a single anterior field including the cervical, axillary, mediastinal, paraaortic, iliac, and inguinal lymph node chains at a dose rate of 4.6 to 4.8cGy/minute. Renal allografts from unrelated monkey donors were placed following LI. Graft function was monitored by urine output, serum BUN and creatinine, and renal biopsy. Low dose rate LI was well tolerated. The absolute lymphocyte count fell from a pre-LI level of 3080 +- 1227/mm3 to 534 +- 478/mm3 at 1 month post-LI. In 4 animals that received no LI (controls), survival post-transplant was 8 to 11 days prior to death from acute rejection. Five animals received transplants immediately following LI. Four survived 11 to 56 days prior to death of presumed infection. One died at day 45 with rejection. Another group of two animals received transplants 3-1/2 weeks after LI. One died of rejection at day 42. One remains well at day 394 post-transplant.
- Research Organization:
- Massachusetts General Hospital, Boston
- OSTI ID:
- 5742511
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IMMUNITY
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
HODGKINS DISEASE
KIDNEYS
LYMPH NODES
LYMPHOCYTES
MONKEYS
MONOCLONAL ANTIBODIES
PARTIAL BODY IRRADIATION
PATIENTS
TRANSPLANTS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
EXTERNAL IRRADIATION
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MATERIALS
NEOPLASMS
ORGANS
PRIMATES
RADIATION EFFECTS
SOMATIC CELLS
VERTEBRATES
560151* - Radiation Effects on Animals- Man
560152 - Radiation Effects on Animals- Animals