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Title: Neurotoxicity of methylmercury in the pigeon

Abstract

Pigeons repeatedly exposed to sublethal doses of methylmercury (5-10 mg Hg/kg/wk, po, for 34-77 days) exhibited marked behavioral changes that were accompanied by only minor evidence of neuropathologic changes at the light microscopic level. Accuracy and rate of pecking for grain declined while food intake remained unchanged. Methylmercury produced permanent changes in posture and in motor coordination. The regional distribution of methylmercury within the nervous system was poorly correlated with the distribution of pathologic changes. Overt behavioral signs appeared after the brain accumulated more than about 12 to 16 ppm Hg. Data with pigeons support earlier evidence that the dose-response function for methylmercury is modulated by dose rate and duration of exposure, since the pattern of blood and tissue distribution of Hg is established in advance of the appearance of signs. The pigeon is more sensitive to methylmercury than are mice and rats, but less sensitive than primates.

Authors:
; ;
Publication Date:
Research Org.:
Institute of Environmental Medicine, New York University Medical Center, NY
OSTI Identifier:
5741149
Resource Type:
Journal Article
Journal Name:
Neurotoxicology; (United States)
Additional Journal Information:
Journal Volume: 3:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BIRDS; SENSITIVITY; METHYLMERCURY; TOXICITY; BEHAVIOR; DOSE-RESPONSE RELATIONSHIPS; NERVOUS SYSTEM; PATHOLOGICAL CHANGES; ANIMALS; MERCURY COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC MERCURY COMPOUNDS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Evans, H L, Garman, R H, and Laties, V G. Neurotoxicity of methylmercury in the pigeon. United States: N. p., 1982. Web.
Evans, H L, Garman, R H, & Laties, V G. Neurotoxicity of methylmercury in the pigeon. United States.
Evans, H L, Garman, R H, and Laties, V G. Mon . "Neurotoxicity of methylmercury in the pigeon". United States.
@article{osti_5741149,
title = {Neurotoxicity of methylmercury in the pigeon},
author = {Evans, H L and Garman, R H and Laties, V G},
abstractNote = {Pigeons repeatedly exposed to sublethal doses of methylmercury (5-10 mg Hg/kg/wk, po, for 34-77 days) exhibited marked behavioral changes that were accompanied by only minor evidence of neuropathologic changes at the light microscopic level. Accuracy and rate of pecking for grain declined while food intake remained unchanged. Methylmercury produced permanent changes in posture and in motor coordination. The regional distribution of methylmercury within the nervous system was poorly correlated with the distribution of pathologic changes. Overt behavioral signs appeared after the brain accumulated more than about 12 to 16 ppm Hg. Data with pigeons support earlier evidence that the dose-response function for methylmercury is modulated by dose rate and duration of exposure, since the pattern of blood and tissue distribution of Hg is established in advance of the appearance of signs. The pigeon is more sensitive to methylmercury than are mice and rats, but less sensitive than primates.},
doi = {},
url = {https://www.osti.gov/biblio/5741149}, journal = {Neurotoxicology; (United States)},
number = ,
volume = 3:3,
place = {United States},
year = {1982},
month = {11}
}