Early methylmercury signs revealed in visual tests. [In monkeys]
Conference
·
OSTI ID:7268673
Since overt signs of methylmercury poisoning seem to reflect damage to the central nervous system, the present study employed behavioral tests suited for repeated measurement during a long exposure and recovery period. The most prominent early signs in monkeys involve sensory impairment. Of these, visual deficits have been the most readily quantified. Reduced sensitivity to extremely dim light could be measured many weeks prior to the appearance of overt signs. Deficits in skin senses and intention tremor also were early signs. Additional signs were described in the temporal progression, from the earliest signs through severe intoxication. With dose and blood mercury concentration held constant, the number and severity of signs progresses as a function of duration exposure.
- Research Organization:
- Rochester Univ., N.Y. (USA)
- OSTI ID:
- 7268673
- Report Number(s):
- UR-3490-815; CONF-7510110-1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYL RADICALS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
MAMMALS
MERCURY
METALS
METHYL RADICALS
MONKEYS
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADICALS
SENSE ORGANS
TESTING
TIME DEPENDENCE
TOXICITY
VERTEBRATES
VISION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYL RADICALS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
MAMMALS
MERCURY
METALS
METHYL RADICALS
MONKEYS
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADICALS
SENSE ORGANS
TESTING
TIME DEPENDENCE
TOXICITY
VERTEBRATES
VISION