Estimation of absorbed doses in humans due to intravenous administration of fluorine-18-fluorodeoxyglucose in PET studies

Journal Article · Mon Apr 01 00:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5735796

Mejia, A A; Nakamura, T; Masatoshi, I; Hatazawa, J; Masaki, M; Watanuki, S ^[1]

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1. Tohoku Univ., Aramaki-Aoba (Japan)

Radiation absorbed doses due to intravenous administration of fluorine-18-fluorodeoxyglucose in positron emission tomography (PET) studies were estimated in normal volunteers. The time-activity curves were obtained for seven human organs (brain, heart, kidney, liver, lung, pancreas, and spleen) by using dynamic PET scans and for bladder content by using a single detector. These time-activity curves were used for the calculation of the cumulative activity in these organs. Absorbed doses were calculated by the MIRD method using the absorbed dose per unit of cumulated activity, 'S' value, transformed for the Japanese physique and the organ masses of the Japanese reference man. The bladder wall and the heart were the organs receiving higher doses of 1.2 x 10(-1) and 4.5 x 10(-2) mGy/MBq, respectively. The brain received a dose of 2.9 x 10(-2) mGy/MBq, and other organs received doses between 1.0 x 10(-2) and 3.0 x 10(-2) mGy/MBq. The effective dose equivalent was estimated to be 2.4 x 10(-2) mSv/MBq. These results were comparable to values of absorbed doses reported by other authors on the radiation dosimetry of this radiopharmaceutical.

• OSTI ID: 5735796
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:4; ISSN 0161-5505
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOPHARMACEUTICALS
DOSIMETRY
DOSE EQUIVALENTS
FLUORINE 18
GLUCOSE
INTRAVENOUS INJECTION
METABOLISM
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
TISSUE DISTRIBUTION
ALDEHYDES
BETA DECAY RADIOISOTOPES
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DIAGNOSTIC TECHNIQUES
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DOSES
DRUGS
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FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MONOSACCHARIDES
NANOSEC LIVING RADIOISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics