Estimated radiation dose to the newborn in FDG-PET studies

Journal Article · Thu Feb 01 04:00:00 EST 1996 · Journal of Nuclear Medicine

OSTI ID:381135

Ruotsalainen, U; Suhonen-Polvi, H; Eronen, E; Kinnala, A ^[1]

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1. Abo Akademi Univ., Turku (Finland)

The aim of this study was to estimate the radiation dose due to intravenous injection of 2-[{sup 18}F]fluoro-2-deoxy-D-glucose (FDG) for infants studied with PET. The radioactivity concentration in the brain and bladder content was measured with PET to determine the cumulated activity in these organs in 21 infant FDG studies. The individual organ masses were estimated according to the whole-body and brain masses, and they were used to calculate the absorbed dose per unit cumulated activity (S values). For organs other than brain and bladder, the cumulated activity was defined from adult studies. For each individual patient, the absorbed dose to the brain, bladder wall and selected organs were calculated. An estimation of the effective dose was determined. Whole-body distribution of FDG in the infants differed from adults: a greater proportion of the injected activity accumulated into the brain (9% versus 7%) and less was excreted to urine (7% versus 20% respectively). The measured cumulated activity in the brain was 0.25 MBq {center_dot} h/MBq and in the bladder content 0.04 MBq {center_dot}h/MBq with a large individual variation in latter. The calculated absorbed dose was 0.24 mGy/MBq to the brain and 1.03 mGy/MBq to the bladder wall. The estimated effective dose was 0.43 mSv/MBq. The dose to the bladder wall was lower in infants as compared to adults with ordinary amounts of injected activity. The greater amount of activity remaining in the body may increase the dose to other organs. The effective dose was lower compared to adults and conventional nuclear medicine studies of infants. PET can be a valuable tool in pediatric nuclear medicine because of good resolution images, sensitive radiation measurement and a variety of tracers labeled with short-lived isotopes. 27 refs., 4 figs., 2 tabs.

• OSTI ID: 381135
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: 2 Vol. 37; ISSN 0161-5505; ISSN JNMEAQ
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL LOCALIZATION
BLADDER
BRAIN
FLUORINE 18
FLUORODEOXYGLUCOSE
IMAGES
INFANTS
INTRAVENOUS INJECTION
LABELLED COMPOUNDS
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
RADIOACTIVITY