Primary aldosteronism: diagnosis, localization, and treatment
Journal Article
·
· Ann. Intern. Med.; (United States)
- Indiana Univ. School of Medicine, Indianapolis
New diagnostic techniques have enhanced the detection of primary aldosteronism. However, the response of blood pressure after operation in unilateral and bilateral adrenal disease is different. We have compared four localizing techniques - adrenal venography, adrenal isotopic scanning, a modified adrenal venous sampling for steroid measurements, and the anomalous postural decrease in plasma aldosterone concentration - in 51 patients with primary aldosteronism, all of whom had undergone operative confirmation. Adrenalectomy resulted in normal blood pressure in 59%, improvement in 25%, and no change in 16%. Correct localization of the lesion was obtained in 47% by the adrenal isotopic scan, in 66% by adrenal venography, and in 91% by the modified adrenal venous hormone technique despite four false-positives. Of the 26 patients with an anomalous postural decrease in plasma aldosterone, 88% had a unilateral lesion.
- OSTI ID:
- 5734009
- Journal Information:
- Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 90:3; ISSN AIMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
ADRENAL HORMONES
ADRENALECTOMY
ALDEHYDES
ALDOSTERONE
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CORTICOSTEROIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYDROXY COMPOUNDS
HYPERTENSION
KETONES
MEDICINE
MINERALOCORTICOIDS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PREGNANES
RADIOISOTOPE SCANNING
RADIOLOGY
SCINTISCANNING
STEROID HORMONES
STEROIDS
SURGERY
SYMPTOMS
VASCULAR DISEASES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
ADRENAL HORMONES
ADRENALECTOMY
ALDEHYDES
ALDOSTERONE
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CORTICOSTEROIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYDROXY COMPOUNDS
HYPERTENSION
KETONES
MEDICINE
MINERALOCORTICOIDS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PREGNANES
RADIOISOTOPE SCANNING
RADIOLOGY
SCINTISCANNING
STEROID HORMONES
STEROIDS
SURGERY
SYMPTOMS
VASCULAR DISEASES