Metabolic rationale for the weak mutagenic and carcinogenic activity of benzo(e)pyrene
Conference
·
OSTI ID:5732395
Benzo(e)pyrene is a weak carcinogen and mutagen in contrast to theoretical calculations that predict substantial carcinogenic potential for this positional isomer of benzo(a)pyrene. Earlier short-term studies have shown metabolism in intact cells strongly favor attack of B(e)P by the mixed function oxidases at the K-region and distal to the bay-region. Current studies have extended incubation times to four days to determine if long-term induction would result in formation of bay-region metabolites and could account for the weak positive carcinogenic and mutagenic activity reported in the literature.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5732395
- Report Number(s):
- CONF-810992-2; ON: DE82002854
- Country of Publication:
- United States
- Language:
- English
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Sat Dec 31 23:00:00 EST 1977
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OSTI ID:6539819
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Related Subjects
550200 -- Biochemistry
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AROMATICS
BENZOPYRENE
CARCINOGENESIS
CELL CULTURES
CONDENSED AROMATICS
ENZYMES
HYDROCARBONS
ISOMERS
METABOLISM
METABOLITES
MIXED-FUNCTION OXIDASES
MUTAGENESIS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
PATHOGENESIS
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AROMATICS
BENZOPYRENE
CARCINOGENESIS
CELL CULTURES
CONDENSED AROMATICS
ENZYMES
HYDROCARBONS
ISOMERS
METABOLISM
METABOLITES
MIXED-FUNCTION OXIDASES
MUTAGENESIS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
PATHOGENESIS