Dosimetry and radiobiology of synchrotron-produced ultrasoft X-rays
Thesis/Dissertation
·
OSTI ID:5730361
Ultrasoft X-rays provide a unique tool to study the mechanism of radiation damage in biological systems. Experimenters have used X-ray tubes with titanium, copper, silver, magnesium, aluminum and carbon targets to generate characteristic X-rays of these materials to irradiate a variety of mammalian cell lines. Limitations in the photon intensity and the available energies from X-ray tube sources prevent definitive characterization of a relationship between photon energy and biological damage. Synchrotron radiation is a useful alternative source of low energy photons since it is available with high intensity over a continuous spectrum. A system was established including an appropriate dosimetry protocol and a workable system for conducting biology studies. A characterization of the system including spectral and intensity properties of the photon beam is presented. Cell survival curves for C3H/10T1/2 show increased efficiency for cell killing for 1-4 keV photons with respect to 250 kVp X-rays.
- Research Organization:
- Wisconsin Univ., Madison, WI (USA)
- OSTI ID:
- 5730361
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BREMSSTRAHLUNG
CELL KILLING
DOSIMETRY
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
MEDICINE
NUCLEAR MEDICINE
PHOTON BEAMS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION SOURCES
RADIATIONS
RADIOLOGY
SURVIVAL CURVES
SYNCHROTRON RADIATION
USES
X RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BREMSSTRAHLUNG
CELL KILLING
DOSIMETRY
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
MEDICINE
NUCLEAR MEDICINE
PHOTON BEAMS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION SOURCES
RADIATIONS
RADIOLOGY
SURVIVAL CURVES
SYNCHROTRON RADIATION
USES
X RADIATION