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Prostatic biopsy after irradiation therapy for prostatic cancer

Journal Article · · Urology (Ridgewood, N.J.); (United States)
OSTI ID:5727314
;
To determine the prognostic significance of a routine needle biopsy of the prostate performed six to thirty-six months after the completion of definitive radiotherapy, biopsy results were analyzed in 146 patients who had no evidence of disease at the time of biopsy and who received no other therapy before proved recurrence of the tumor. Patients were followed up a mean of 3.9 years after radioactive gold seed implantation and external beam irradiation. The total dose was 8,000 rad. Among 146 patients, 56 (38%) had one or more positive biopsy results within this time interval. The positive biopsy rate correlated with the clinical stage ranging from 17 per cent in Stage B1N to 59 per cent in Stage C1. The risk of developing local recurrence or distant metastases at any given time after irradiation therapy was markedly greater in those patients with a positive biopsy result (p less than 0.0005). Prostatic biopsy is an accurate means of measuring the success of radiotherapy. A positive postirradiation biopsy result carries grave prognostic implications for the patient and indicates that the treatment has failed.
Research Organization:
Baylor College of Medicine, Houston, TX
OSTI ID:
5727314
Journal Information:
Urology (Ridgewood, N.J.); (United States), Journal Name: Urology (Ridgewood, N.J.); (United States) Vol. 25:2 Suppl; ISSN URGYA
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOPSY
BODY
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
ELEMENTS
GLANDS
GOLD
IMPLANTS
MALE GENITALS
MEDICINE
METALS
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROSTATE
RADIATION DOSES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
THERAPY
TRANSITION ELEMENTS