Metabolism of hydrazine. Final report 1 Oct 79-30 Sep 80. [Rats]
In rats exposed to atmospheric hydrazine, the log of blood hydrazine concentration was found to bear a more or less linear relation to atmospheric hydrazine levels. At 20-25 mg hydrazine/cu M, blood concentrations approached 100 nmole/ml, and were about 2 nmole/ml at atmospheric concentrations of about 3 mg/cu M. During exposure, blood concentrations tended to rise rather quickly in the first hour, then oscillated slowly around a generally constant level throughout six hours of exposure. Blood concentration of hydrazine following a single 1 nmole/kg dose decreased with a first phase halftime of about 45 minutes followed by a slower decrease with halftime of 27 hours. Less than one percent of such doses was excreted in bile. In vitro reaction of 5 m molar hydrazine in whole blood proceeded at a rate of about .016 micromole/m1/minute or about 10% in 30 minutes. With higher concentrations turnover becomes more rapid and can exceed the hemoglobin subunit equivalence by many fold. Extensive efforts to locate 15N/labelled urinary metabolities that would account for remaining uninventoried hydrazine have not yet succeeded.
- Research Organization:
- Oregon State Univ., Corvallis (USA). Dept. of Agricultural Chemistry
- OSTI ID:
- 5724850
- Report Number(s):
- AD-A-101849/8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HYDRAZINE
METABOLISM
BIOLOGICAL ACCUMULATION
BLOOD CHEMISTRY
EXCRETION
HEMOGLOBIN
LABELLED COMPOUNDS
MASS SPECTROSCOPY
METABOLITES
NITROGEN
RADIOISOTOPES
RATS
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACIDS
CLEARANCE
ELEMENTS
GLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ISOTOPES
MAMMALS
MATERIALS
NITROGEN COMPOUNDS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RODENTS
SPECTROSCOPY
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)