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Structure and expression of the murine N-myc gene

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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The authors have demonstrated that the entire murine N-myc gene and the sequences necessary for its expression in human neuroblastoma cells are contained within a 7.4-kilobase murine genomic clone. The complete nucleotide sequence of this gene reveals a number of striking similarities and differences when compared to the related c-myc gene including the following: (i) each gene contains three exons of which the first encodes a long 5'-untranslated leader sequence; (ii) the coding regions of the N- and c-myc genes share regions of substantial nucleic acid homology, the putative N-myc protein shares substantial homology with the c-myc protein; (iii) as with c-myc, extensive nucleotide sequence homology exists between the untranslated regions of the human and murine N-myc gene transcripts; however, the N-myc and c-myc untranslated regions are totally divergent; (iv) the N-myc transcriptional promoter differs from that of c-myc and is more related to the promoter of the simian virus 40. They discuss these findings in the context of previously defined similarities and differences in the potential functional and regulatory aspects of these two myc-family members.
Research Organization:
Columbia Univ., New York, NY
OSTI ID:
5722450
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 83:6; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DNA
DNA SEQUENCING
GENE REGULATION
GENES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAN
MICE
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ONCOGENES
ORGANIC COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
RODENTS
STRUCTURAL CHEMICAL ANALYSIS
TUMOR CELLS
VERTEBRATES