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Activation of calcium transport into synaptosomes by phospholipase C specific for phosphatidylinositols

Journal Article · · Biochemistry (Engl. Transl.); (United States)
OSTI ID:5722253
; ; ; ;

The influence of phospholipases C of various origin and specificity on the level of accumulation of calcium by synaptosomes isolated from the rat brain was investigated with the aid of an isotope label. It was shown that phosphatidylinositol-specific phospholipases C can stimulate Ca/sup 2 +/ transport into synaptosomes, whereas phospholipase C exhibiting no specific effect on any fraction of the membrane lipids is ineffective or lowers the level of accumulation of calcium by the synaptosomes. The detected effects can be explained by activation of the phosphatidylinositol metabolism and an increase in the content in the synaptosomal membranes of its products that activate calcium transport, as well as a partial destruction of the membranes under the action of phospholipases.

Research Organization:
M.V. Lomonosov Moscow State Univ., USSR
OSTI ID:
5722253
Journal Information:
Biochemistry (Engl. Transl.); (United States), Journal Name: Biochemistry (Engl. Transl.); (United States) Vol. 51:8; ISSN BIORA
Country of Publication:
United States
Language:
English

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Related Subjects

550301* -- Cytology-- Tracer Techniques
550501 -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BODY
BRAIN
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CARBOHYDRATES
CARBOXYLESTERASES
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CYTOCHEMISTRY
DAYS LIVING RADIOISOTOPES
ENZYME ACTIVITY
ENZYMES
ESTERASES
ESTERS
EVEN-ODD NUCLEI
HYDROLASES
INOSITOLS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIPASE
LIPIDS
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
METABOLIC ACTIVATION
METABOLISM
MONOSACCHARIDES
NERVE CELLS
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SACCHARIDES
SOMATIC CELLS
STIMULATION
TRACER TECHNIQUES
VERTEBRATES