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Interaction of serum sex steroid-binding globulin with cell membranes of human decidual tissue

Journal Article · · Biochemistry (Engl. Transl.); (United States)
OSTI ID:5721975
; ;

The interaction of the sex steroid-binding globulin (SBG) of human blood with plasma membranes of cells from human decidual tissue - the target tissue of estradiol - was studied. It was shown that SBG in complex with estradiol is capable of interacting specifically with these membranes. The dissociation (K/sub dis/) of this interaction is equal to (3.5 +/- 2.0) 10/sup -12/ M. The interaction of the SBG-estradiol complex with the membranes is characterized by high selectivity: such blood serum globulins as albumin, orosomucoid, transferrin, transcortin, and thyroxine-binding globulin do not compete with SBG for its binding sites on the membranes. The SBG-testosterone complex and SBG without steroid are also incapable of interacting with the membranes.

Research Organization:
Institute of Bioorganic Chemistry, Minsk, USSR
OSTI ID:
5721975
Journal Information:
Biochemistry (Engl. Transl.); (United States), Journal Name: Biochemistry (Engl. Transl.); (United States) Vol. 50:7; ISSN BIORA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
ANDROSTANES
ANIMALS
BETA DECAY RADIOISOTOPES
BINDING ENERGY
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHEMISTRY
COMPLEXOMETRY
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ENERGY
ESTRADIOL
ESTRANES
ESTROGENS
GLOBULINS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
KINETICS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MAN
MATERIALS
MEMBRANE PROTEINS
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOISOTOPES
RADIORECEPTOR ASSAY
REACTION KINETICS
RECEPTORS
RETENTION
STEROID HORMONES
STEROIDS
TESTOSTERONE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES