Regional cerebral palmitate incorporation following transient bilateral carotid occlusion in awake gerbils

Journal Article · Sun Nov 01 04:00:00 EST 1987 · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.18.6.1120· OSTI ID:5721092

Tone, O; Miller, J C; Bell, J M; Rapoport, S I

(/sup 14/C)Palmitate was injected intravenously in awake gerbils at various times after 5 minutes of bilateral carotid artery occlusion or a sham operation. Regional rates of incorporation of plasma palmitate into the hippocampus and other regions of the anterior circulation were determined relative to the mean rate of incorporation into regions of the posterior circulation using quantitative autoradiography and a ratio method of analysis. One day after bilateral carotid occlusion, relative palmitate incorporation was elevated significantly by 16% in the CA4 pyramidal cell layer and by 20% in the dentate gyrus of the hippocampus compared with sham-operated gerbils. At 3 days, significant elevations of this magnitude were found in the CA3 and CA4 cell layers, whereas relative incorporation was reduced by 26% in the CA1 pyramidal cell layer. At 7 days, the only significant difference from control was a 15% elevated incorporation in the CA3 pyramidal cell layer. Histologic examination indicated substantial cell death in the CA1 pyramidal layer at 3 days, with extensive glial reaction and phagocytic invasion at 7 days. Our results suggest that the turnover of palmitate-containing lipids is reduced in the CA1 layer of the gerbil hippocampus but that lipid synthesis is stimulated in hippocampal regions (CA3, CA4, dentate gyrus) affected by but recovering from transient bilateral carotid occlusion.

• Research Organization: National Institute on Aging, Bethesda, MD
• OSTI ID: 5721092
• Journal Information: Stroke; (United States), Journal Name: Stroke; (United States) Vol. 18:6; ISSN SJCCA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARTERIES
AUTORADIOGRAPHY
BIOSYNTHESIS
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARBON 14 COMPOUNDS
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
DISEASES
GERBILS
HIPPOCAMPUS
INJECTION
INTAKE
INTRAVENOUS INJECTION
LABELLED COMPOUNDS
LIPIDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
SYNTHESIS
VASCULAR DISEASES
VERTEBRATES