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Effect of sterol metabolism in the yeast-Drosophila system on the frequency of radiation-induced aneuploidy in the Drosophila melanogaster oocytes

Journal Article · · Sov. Genet. (Engl. Transl.); (United States)
OSTI ID:5719620
; ;
The effect of sterol metabolism on induced mutagenesis of Drosophila melanogaster was studied in the ecogenetic system of yeast-Drosophila. Sterol deficiency was created in Drosophila by using the biomass of live cells of Saccharomyces cerevisiae strain 9-2-P712 till mutation in locus nys/sup r1/ blocking the synthesis of ergosterol as the food. It was found that rearing of Drosophila females on the mutant yeast increases the frequency of loss and nondisjunction of X chromosomes induced in mature oocytes by X rays (1000 R). Addition of 0.1% of cholesterol solution in 10% ethanol to the yeast biomass restores the resistance of oocyte to X irradiation to the control level. The possible hormonal effect on membrane leading to increased radiation-induced aneuploidy in Drosophila and the role of sterol metabolism in determining the resistance to various damaging factors are discussed.
Research Organization:
A. A. Zhdanov Leningrad State Univ., USSR
OSTI ID:
5719620
Journal Information:
Sov. Genet. (Engl. Transl.); (United States), Journal Name: Sov. Genet. (Engl. Transl.); (United States) Vol. 21:7; ISSN SOGEB
Country of Publication:
United States
Language:
English

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Related Subjects

550400 -- Genetics
550500 -- Metabolism
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANEUPLOIDY
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BIOSYNTHESIS
CHOLESTEROL
CHROMOSOMAL ABERRATIONS
CHROMOSOME LOSSES
CHROMOSOMES
DIPTERA
DROSOPHILA
ELECTROMAGNETIC RADIATION
ERGOSTEROL
ETHANOL
FLIES
FRUIT FLIES
FUNGI
GENETICS
GERM CELLS
HETEROCHROMOSOMES
HYDROXY COMPOUNDS
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
LOSSES
METABOLISM
MICROORGANISMS
MUTAGENESIS
MUTANTS
MUTATIONS
NON-DISJUNCTION
OOCYTES
ORGANIC COMPOUNDS
PLANTS
PLOIDY
RADIATION EFFECTS
RADIATIONS
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
STEROIDS
STEROLS
SYNTHESIS
X CHROMOSOME
X RADIATION
YEASTS