QSAR analysis and data extrapolation among mammals in a series of aliphatic alcohols
Journal Article
·
· Environ. Health Perspect.; (United States)
Concepts of QSAR analysis and biological similarity models are combined for use in extrapolation of LD/sub 50/ values after IP application of a series of aliphatic alcohols (C/sub 1/-C/sub 5/) to mouse, hamster, rat, and guinea pig and rabbit. It has been found that although close correlation exists between LD/sub 50/ values after IP and IV applications for mouse and rat, the QSAR obtained with LD/sub 50/ after IV application are not suitable for a prediction of LD/sub 50/ values after IP application for rabbit. Different transformation or distribution processes in mouse, rat, and rabbit after the two types of applications might be the reason. The LD/sub 50/ values (expressed in mmole/m/sup 2/ of body surface) seem to be independent of mammalian species used (at least within the mouse, rat, hamster, and probably guinea pig series). This fact makes it possible to predict reasonable values of LD/sub 50/ after IP application for rabbit. Expression of toxicity in mmole/m/sup 2/ of body surface may be used in toxicological studies. 24 references, 2 figures, 8 tables.
- Research Organization:
- Institute of Hygiene and Epidemiology, Praha, Czechoslovakia
- OSTI ID:
- 5718565
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 61; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
Similar Records
PERSISTENCE OF HETEROLOGOUS BONE MARROW IN MICE AS FUNCTION OF X-RAY DOSE
THE RELATIVE RADIOSENSITIVITY OF THE GENETIC STRUCTURE OF MAMMALIAN CELLS IN VITRO
THE INFLUENCE OF DELIVERY RATE OF WHOLE BODY 250 KV. ROENTGEN IRRADIATION (30 OR 3 ROENTGENS PER MINUTE) ON MICE, RATS AND GUINEA PIGS
Journal Article
·
Sat Jan 31 23:00:00 EST 1959
· Proc. Soc. Exptl. Biol. Med.
·
OSTI ID:4254153
THE RELATIVE RADIOSENSITIVITY OF THE GENETIC STRUCTURE OF MAMMALIAN CELLS IN VITRO
Journal Article
·
Fri Oct 11 00:00:00 EDT 1963
· Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals
·
OSTI ID:4162425
THE INFLUENCE OF DELIVERY RATE OF WHOLE BODY 250 KV. ROENTGEN IRRADIATION (30 OR 3 ROENTGENS PER MINUTE) ON MICE, RATS AND GUINEA PIGS
Journal Article
·
Sat Oct 01 00:00:00 EDT 1960
· Am. J. Roentgenol., Radium Therapy Nuclear Med.
·
OSTI ID:4153915
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL MODELS
DISTRIBUTION
DOSES
EXTRAPOLATION
FORECASTING
GUINEA PIGS
HAMSTERS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
LETHAL DOSES
MAMMALS
MICE
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
RABBITS
RATS
RODENTS
STRUCTURE-ACTIVITY RELATIONSHIPS
SURFACE AREA
SURFACE PROPERTIES
TISSUE DISTRIBUTION
VERTEBRATES
WEIGHT
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL MODELS
DISTRIBUTION
DOSES
EXTRAPOLATION
FORECASTING
GUINEA PIGS
HAMSTERS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
LETHAL DOSES
MAMMALS
MICE
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
RABBITS
RATS
RODENTS
STRUCTURE-ACTIVITY RELATIONSHIPS
SURFACE AREA
SURFACE PROPERTIES
TISSUE DISTRIBUTION
VERTEBRATES
WEIGHT