Autofluorescence maps of atherosclerotic human arteries - A new technique in medical imaging

Journal Article · Thu Oct 01 04:00:00 EDT 1987 · IEEE J. Quant. Electron.; (United States)

DOI:https://doi.org/10.1109/JQE.1987.1073221· OSTI ID:5718345

Sartori, M; Sauerbrey, R; Kubodera, S; Tittel, F K; Roberts, R; Henry, P D

A new medical imaging technique for arterial walls based on laser-induced autofluorescence spectroscopy is reported. The internal surface of isolated arteries with or without atherosclerosis is irradiated with an argon ion laser (458 nm) and the peak intensity of the excited autofluorescence spectrum is related to the composition of the arterial wall. The higher autofluorescence intensity in the range between approximately 480 and 630 nm for grossly calcified tissue compared to normal or noncalcified atherosclerotic tissue is used to produce maps of the arterial wall. These images delineate the calcified areas of the sample with good spatial resolution. If this technique can be adapted to the endoscopic visualization of arteries in vivo (angioscopy), it could become an important tool for the diagnosis of atherosclerosis and for the monitoring of atheroma ablation during laser angioplasty.

• Research Organization: Section of Cardiology, Baylor College of Medicine, Houston, TX 77030
• OSTI ID: 5718345
• Journal Information: IEEE J. Quant. Electron.; (United States), Journal Name: IEEE J. Quant. Electron.; (United States) Vol. QE-23:10; ISSN IEJQA
• Country of Publication: United States
• Language: English

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550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
ARTERIOSCLEROSIS
AUTORADIOGRAPHY
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EMISSION SPECTROSCOPY
FLUORESCENCE SPECTROSCOPY
FLUOROSCOPY
IMAGE PROCESSING
MEDICINE
NUCLEAR MEDICINE
ORGANS
PROCESSING
RADIOLOGY
SPECTROSCOPY
USES
VASCULAR DISEASES