Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline
Journal Article
·
· Am. J. Cardiol.; (United States)
Tetracycline is an antibiotic that absorbs ultraviolet light at 355 nm and preferentially binds to atherosclerotic plaque both in vitro and in vivo. Tetracycline-treated human cadaveric aorta was compared with untreated aorta using several techniques: absorptive spectrophotometry; and tissue uptake of radiolabeled tetracycline, which showed 4-fold greater uptake by atheroma than by normal vessel. In addition, intravenous tetracycline administered to patients undergoing vascular surgery demonstrated characteristic fluorescence in surgically excised diseased arteries. Because of tetracycline's unique properties, the authors exposed tetracycline-treated and untreated aorta to ultraviolet laser radiation at a wavelength of 355 nm. They found enhanced ablation of tetracycline-treated atheroma compared with untreated atheroma. The plaque ablation caused by ultraviolet laser radiation was twice as extensive in tetracycline-treated vs nontreated plaque. This study demonstrates the potential of tetracycline plaque enhancement for the selective destruction of atheroma by ultraviolet laser radiation.
- Research Organization:
- Stanford Univ. Medical Center, CA
- OSTI ID:
- 5175276
- Journal Information:
- Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 11; ISSN AJCDA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Detection of early stage atherosclerotic plaques using PET and CT fusion imaging targeting P-selectin in low density lipoprotein receptor-deficient mice
Laser ablation of atherosclerotic blood vessel tissue under various irradiation conditions
Primary Stenting for Complex Atherosclerotic Plaques in Aortic and Iliac Stenoses
Journal Article
·
Fri Mar 29 00:00:00 EDT 2013
· Biochemical and Biophysical Research Communications
·
OSTI ID:22239527
Laser ablation of atherosclerotic blood vessel tissue under various irradiation conditions
Journal Article
·
Thu Nov 30 23:00:00 EST 1989
· IEEE Transactions on Bio-Medical Engineering (Institute of Electrical and Electronics Engineers); (USA)
·
OSTI ID:6982810
Primary Stenting for Complex Atherosclerotic Plaques in Aortic and Iliac Stenoses
Journal Article
·
Tue Sep 15 00:00:00 EDT 1998
· Cardiovascular and Interventional Radiology
·
OSTI ID:21080375
Related Subjects
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AORTA
ARTERIES
ARTERIOSCLEROSIS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
FLUORESCENCE
IN VITRO
LABELLED COMPOUNDS
LASER RADIATION
LUMINESCENCE
NEAR ULTRAVIOLET RADIATION
ORGANS
RADIATIONS
SPECTROPHOTOMETRY
TETRACYCLINES
ULTRAVIOLET RADIATION
UPTAKE
VASCULAR DISEASES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AORTA
ARTERIES
ARTERIOSCLEROSIS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
FLUORESCENCE
IN VITRO
LABELLED COMPOUNDS
LASER RADIATION
LUMINESCENCE
NEAR ULTRAVIOLET RADIATION
ORGANS
RADIATIONS
SPECTROPHOTOMETRY
TETRACYCLINES
ULTRAVIOLET RADIATION
UPTAKE
VASCULAR DISEASES