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Radiosensitivity of mouse lip mucosa: Influence of anesthesia, carbogen, and a new high O/sub 2/ carrying perfluorochemical emulsion

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3577407· OSTI ID:5715306
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The effect of a new perfluorochemical emulsion based on F-66E (54%, w/v) which carries, in combination with carbogen, twice as much oxygen as Fluosol-DA 20% was tested on the radiation response of the lip mucosa of unanesthetized mice. Mice were pretreated with 0.015 ml/g of the F-66E emulsion in the presence of carbogen for 1 h prior to and during irradiation. There was a significant increase in the mortality rate following the highest radiation dose in mice given F-66E emulsion plus carbogen. The reactions of lip mucosa of mice given F-66E emulsion and/or carbogen were not significantly different from that of the control group using three end points (average score, mean peak, incidence of mucosal desquamation), but the peak mucosal reaction was delayed. The radiosensitivity of the mouse lip mucosa to Ethrane, an anesthetic gas inhaled with carbogen, was also tested. The reaction of lip mucosa in the anesthetized mice was significantly greater than that of the control group. There was also a significant increase in the mortality rate following the two highest radiation doses.

Research Organization:
Institut Gustave-Roussy, Villejuif (France)
OSTI ID:
5715306
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 118:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHESIA
ANIMALS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
DOSES
ELEMENTS
EMULSIONS
FLUORINE COMPOUNDS
HALOGEN COMPOUNDS
MAMMALS
MEMBRANES
MICE
MORTALITY
MUCOUS MEMBRANES
NONMETALS
ORAL CAVITY
OXIDES
OXYGEN
OXYGEN COMPOUNDS
RADIATION DOSES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
VERTEBRATES