Administration of a perfluorochemical emulsion plus carbogen breathing does not alter radiation pneumonitis

Journal Article · Tue Feb 28 23:00:00 EST 1995 · Proceedings of the Society for Experimental Biology and Medicine

DOI:https://doi.org/10.3181/00379727-208-43858· OSTI ID:241012

Rockwell, S; Kelley, M; Rosiello, R A ^[1]

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1. Yale Univ. School of Medicine, New Haven, CT (United States); and others

The effects of treatment with a perfluorochemical emulsion plus carbogen on radiation pneumonitis were examined in a rat model system. Rats received thoracic irradiation (15 Gy) and radiation reactions in the lungs were assessed 25 and 35 days later using bronchoalveolar lavage and histologic assessments. The irradiated lungs showed the expected evidence of acute radiation pneumonitis, including protein leaks and also alveolar infiltrates and interstitial infiltrates. Administration of a perfluoro-chemical emulsion (Fluosol; 15 ml/kg) plus carbogen breathing for 30 min before and during irradiation did not enhance the reactions seen in the irradiated lungs. 32 refs., 3 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 241012
• Journal Information: Proceedings of the Society for Experimental Biology and Medicine, Journal Name: Proceedings of the Society for Experimental Biology and Medicine Journal Issue: 3 Vol. 208; ISSN PSEBAA; ISSN 0037-9727
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANIMAL CELLS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
PNEUMONITIS
PROTEINS
RADIOTHERAPY
RATS
THERAPY