Ventricular performance in congential left-to-right shunt: temporal Fourier analysis of gated blood-pool data

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · J. Nucl. Med.; (United States)

OSTI ID:5707714

Takeda, K

Using global time-activity curves, the phase and amplitude at fundamental frequency were calculated, and emptying patterns of the right and left ventricles (RV, LV) were evaluated by phase difference and RV/LV amplitude ratio. In 21 subjects with normal cardiac function, D(phase) was minimal (mean 2.2 +- 6.1/sup 0/), regardless of heart rate, and R(amp) was distributed from 0.31 to 0.92 (mean 0.57 +- 0.20). In 19 patients of ventricular septal defect (VSD), R(amp) remained within the normal range, whereas D(phase) became larger in proportion to the ratio of pulmonary-to-systemic blood flow, Qp/Qs (p < 0.001). Especially, cases with Qp/Qs over 2.0 showed a significant RV phase lag. By contrast, nine patients with patent ductus arteriosus (PDA), showed no RV phase lag, but - particularly in cases with Qp/Qs > 2.0 - R(amp) was smaller than normal (p < 0.001). Thus this method is valuable for pathophysiologic investigation of diseases with L-to-R shunt, and can help in the noninvasive differential diagnosis between VSD and PDA.

• Research Organization: Mie Univ. School of Medicine, Tsu, Japan
• OSTI ID: 5707714
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550801 -- Morphology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CONGENITAL MALFORMATIONS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
FOURIER ANALYSIS
HEART
MALFORMATIONS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIOCARDIOGRAPHY