Effects of low lead exposure on neuro-behavioral function in the rat

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1983.10543975· OSTI ID:5706210

Kishi, R ^[1]; Ikeda, T; Miyake, H; Uchino, E; Tsuzuki, T; Inoue, K

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1. Sapporo Medical College, Japan

Small doses (45-180 ..mu..g/g) of lead acetate were administered to male rats by gavage every day during the first 3 wk of life. A blood concentration of approximately 59 ..mu..g/100 ml blood produced signs of disturbances in reflex development and some changes in emotional behavior. Larger doses resulted in subtle changes in the neuromotor coordination function. The effect of low levels of lead exposure on the cognitive function in operant conditioning could not clearly be observed. Brain lead concentration tended to be higher than in other tissues examined. At approximately 10 months following cessation of lead acetate administration, the brain lead concentration had decreased to almost the same level found in control rats, and no distinguishable differences were observed between the lead-treated rats and controls in emotional behavior and neuromotor coordination.

• OSTI ID: 5706210
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 38:12; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
LEAD
MAMMALS
MATERIALS
METALS
NERVOUS SYSTEM
ORGANS
RATS
RODENTS
SENSITIVITY
VERTEBRATES