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Lack of suppressor cell activity in the spleens of mice with radiation-induced osteogenic sarcomas

Journal Article · · Cancer Res.; (United States)
OSTI ID:5706133
;

C57BL/6J mice were used both for induction of osteogenic sarcomas by injection of /sup 90/Sr and for induction of sarcomas and carcinomas by injection of 9,10-dimethyl-1,2-benzanthracene. The osteogenic sarcomas had a relatively long induction period; they possessed low immunogenicity and failed to activate splenic suppressor cells either in the original tumor-bearing host or in mice bearing transplanted osteogenic sarcomas. In contrast, and in agreement with previous work, 9,10-dimethyl-1,2-benzanthracene-induced tumors had a relatively short induction period; they possessed high immunogenicity and activated splenic suppressor cells in mice bearing transplanted tumors. These results suggest the possibility that the immunogenicity of tumors correlates with the ability of tumors to activate suppressor cells.

OSTI ID:
5706133
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 41:3; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DYNAMIC FUNCTION STUDIES
EVEN-EVEN NUCLEI
GRAFT-HOST REACTION
IMMUNITY
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICE
NEOPLASMS
NUCLEI
ORGANS
OSTEOSARCOMAS
PHYSIOLOGY
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RODENTS
SARCOMAS
SKELETAL DISEASES
SOMATIC CELLS
SPLEEN
SPLEEN CELLS
STRONTIUM 90
STRONTIUM ISOTOPES
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES