Survival of spermatogonial stem cells in the mouse after split-dose irradiation with fission neutrons of 1-MeV mean energy

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575098· OSTI ID:5705950

de Ruiter-Bootsma, A L ^[1]; Kramer, M F; de Rooij, D G; Davids, J A.G.

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1. State Univ. Medical School, Utrecht, Netherlands

Spermatogonial stem cells, which survive a neutron dose of 150 rad, all belong to a radioresistant population, characterized in the present study by a D/sub 0/ value for neutrons of 96 +- 5 rad. Shortly after a dose of 150-rad neutrons the surviving stem cells greatly increased in radiosensitivity; at 24 h after this dose they were characterized by a D/sub 0/ of 25 +- 1 rad. At 8 days after 150 rad the D/sub 0/ value was higher; 46 +- 4 rad and it increased further to 54 +- 3 rad at 15 days. The increase in D/sub 0/ ceased between the 15th and 26th day after irradiation; at the latter time a D/sub 0/ of 49 +- 2 rad was found. These data show that during the first 26 days after a dose of 150-rad neutrons the radiosensitivity of the surviving stem cell population first increases and then slowly decreases to stay at a relatively high level of radiosensitivity from 15 days on without signs of a return to the preirradiation value. The stem cell population, although expanding after the first dose, did not return to its normal size within the period investigated.

• OSTI ID: 5705950
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 79:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DOSES
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
GAMETES
GERM CELLS
HADRONS
IRRADIATION
LET
MAMMALS
MICE
NEUTRONS
NUCLEONS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPERMATOGONIA
STEM CELLS
SURVIVAL CURVES
VERTEBRATES