Regression of myelocytic leukemia in rats after hypophysectomy
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
A standard series of five intravenous injections of N-nitroso-N-methylurea (NMU) elicited selective patterns of neoplasms in male rats of the Sprague-Dawley strain; the neoplastic pattern was related to the age of the recipients. When the injections of NMU were started in weanling male rats, a specific triad of neoplasms developed that consisted of mammary carcinoma, primary myelocytic leukemia, and ear duct cancer. When the injections of NMU were started in males at age 100 days, a specific dyad of neoplastic growths was evoked that consisted of primary myelocytic leukemia and ear duct cancer, whereas mammary cancer and other neoplasms were not evident. Secondary myelocytic leukemia and myelocytic sarcoma were produced when blood from the foregoing rats with advanced primary myelocytic leukemia was injected in a subcutaneous site in newborn allogeneic rats. In a proportion of animals, primary and secondary myelocytic leukemia and myelocytic sarcoma underwent dramatic and continued regression after hypophysectomy. 18 references, 3 figures, 3 tables.
- Research Organization:
- Univ. of Chicago, IL
- OSTI ID:
- 5705708
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 81:2; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
CARCINOGENESIS
CARCINOMAS
DATA
DISEASES
EXPERIMENTAL DATA
HEMIC DISEASES
HYPOPHYSECTOMY
INFORMATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
LEUKEMIA
LEUKEMOGENESIS
MAMMALS
MEDICINE
MYELOID LEUKEMIA
NEOPLASMS
NITROSO COMPOUNDS
NITROSOUREAS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SARCOMAS
SURGERY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
CARCINOGENESIS
CARCINOMAS
DATA
DISEASES
EXPERIMENTAL DATA
HEMIC DISEASES
HYPOPHYSECTOMY
INFORMATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
LEUKEMIA
LEUKEMOGENESIS
MAMMALS
MEDICINE
MYELOID LEUKEMIA
NEOPLASMS
NITROSO COMPOUNDS
NITROSOUREAS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SARCOMAS
SURGERY
VERTEBRATES