Studies with a new experimental model in respiratory carcinogenesis

Conference · Sat Jan 01 04:00:00 EST 1977

OSTI ID:5178260

Nettesheim, P.; Yarita, T.

Tracheal tumor induction in hamsters with N-nitroso-N-methylurea (NMU) shows a clear dose-response relationship. Multiple exposures are required to induce tumors. With 10 to 20 exposures, most of the neoplasms occur in the region between the 6th to 13th tracheal rings. With low doses, non-invasive neoplasms are most common. With high doses invasive carcinomas are the most frequent type of tumor. Adeno carcinomas appear to be most common with the lower (0.5 percent) NMU concentration. Small cell carcinomas were induced; whether these are similar to small cell carcinomas in humans remains to be determined. The experimental model described appears to offer many attractive features for the study of neoplastic evolution in respiratory tract epithelium. Every major histological type of neoplasm known to occur in the bronchial tract of humans can be induced in this system.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5178260
• Report Number(s): CONF-771147--1
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
CARCINOGENESIS
CARCINOGENS
CARCINOMAS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HAMSTERS
MAMMALS
NEOPLASMS
PATHOGENESIS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES