Effect of fluorides on hematopoietic system, liver, and thyroid gland in cattle
Thirty-two holstein-friesian heifers, divided into groups and fed 10, 25, 50, and 100 ppm sodium fluoride for approximately 7 1/2 years, were studied to determine the effect of fluoride on the hematopoietic system, liver, and thyroid gland. The composite and individual results of numerous detailed blood studies, identical to those used in evaluating the hematopoietic system in man, established that fluoride, fed daily in concentrations up to 100 ppm for more than seven years, (1) does not show gross, histological or functional effects on the thyroid gland or liver and does not produce significant changes in the serum albumen phosphorus or numerous other blood chemistries studied; (3) had a minimal blood effect in the form of a slightly higher total eosinophil count and a lower level of serum folic acid activity in the 100 ppm group; (4) does not produce anemia or detectable abnormalities of the bone marrow or otherwise affect the hematopoietic system.
- Research Organization:
- Mount Sinai Hospital, New York, NY
- OSTI ID:
- 5705580
- Journal Information:
- JAMA, J. Am. Med. Assoc.; (United States), Vol. 192:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
FLUORIDES
BIOLOGICAL EFFECTS
DOSE-RESPONSE RELATIONSHIPS
BLOOD CELLS
BLOOD CHEMISTRY
BONE MARROW
BONE MARROW CELLS
CHRONIC EXPOSURE
COWS
EXPERIMENTAL DATA
INGESTION
LIVER
THYROID
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CATTLE
CONNECTIVE TISSUE CELLS
DATA
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ENDOCRINE GLANDS
FLUORINE COMPOUNDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEMATOPOIETIC SYSTEM
INFORMATION
INTAKE
MAMMALS
MATERIALS
NUMERICAL DATA
ORGANS
RUMINANTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)