Control of connective tissue metabolism by lasers: recent developments and future prospects
Journal Article
·
· J. Am. Acad. Dermatol.; (United States)
Various laser modalities are currently in extensive use in dermatology and plastic surgery, particularly for treatment of vascular and pigmented lesions. A relatively new area of laser utilization involves the possible biologic effects of the lasers. In this overview, recent studies are summarized which indicate that lasers at specific wavelengths and energy densities modulate the connective tissue metabolism by skin fibroblasts both in vitro and in vivo. Specifically, the neodymium-yttrium-aluminum-garnet (Nd: YAG) laser was shown to selectively suppress collagen production both in fibroblast cultures and in normal skin in vivo, thus suggesting that this laser modality may be useful for the treatment of fibrotic conditions such as keloids and hypertrophic scars. Furthermore, two low-energy lasers, helium-neon (He-Ne) and gallium-arsenide (Ga-As), were shown to stimulate collagen production in human skin fibroblast cultures, suggesting that these lasers could be used for enhancement of wound healing processes. These experimental approaches illustrate the future possibilities for applying lasers for the modulation of various biologic functions of cells in tissues and attest to the potential role of lasers in the treatment of cutaneous disorders.
- OSTI ID:
- 5705233
- Journal Information:
- J. Am. Acad. Dermatol.; (United States), Journal Name: J. Am. Acad. Dermatol.; (United States) Vol. 11:6; ISSN JAADD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
CELL CULTURES
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAS LASERS
HELIUM-NEON LASERS
LASER RADIATION
LASERS
METABOLISM
NEODYMIUM LASERS
ORGANS
RADIATIONS
SKIN
SKIN DISEASES
SOLID STATE LASERS
SOMATIC CELLS
THERAPY
TISSUES
USES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
CELL CULTURES
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAS LASERS
HELIUM-NEON LASERS
LASER RADIATION
LASERS
METABOLISM
NEODYMIUM LASERS
ORGANS
RADIATIONS
SKIN
SKIN DISEASES
SOLID STATE LASERS
SOMATIC CELLS
THERAPY
TISSUES
USES