Multigeneration study of 1,2,4-trichlorobenzene in rats

Journal Article · Tue Sep 01 00:00:00 EDT 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530085· OSTI ID:5704866

Robinson, K S; Kavlock, R J; Chernoff, N; Gray, L E

Rats were continuously exposed to 0, 25, 100, or 400 ppm 1,2,4-trichlorobenzene (TCB) in the drinking water, beginning with birth of the F/sub 0/ generation and continuing through weaning of the F/sub 2/ generation. The treatment did not affect fertility, growth, viability, locomotor activity, or blood chemical analyses. Adrenal gland enlargement was observed in both the F/sub 0/ and F/sub 1/ animals at 95 d of age. To further examine the adrenal enlargement found in the reproduction study, an acute toxicity study was undertaken in which immature females were given ip injections of 0, 250, or 500 mg/kg TCB on 3 consecutive days. It was found that TCB had no estrogenic activity and that the livers and adrenals of treated females were significantly larger than those of controls. Rather than being estrogenic, TCB in this treatment regimen resulted in a decrease in uterine weight. These two studies demonstrate that chronic or acute doses of TCB can produce adrenal enlargement in rats.

• Research Organization: U.S. Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 5704866
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 8:3
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZENE
BIOLOGICAL EFFECTS
CHLORINATED AROMATIC HYDROCARBONS
ADRENAL GLANDS
BLOOD
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FERTILITY
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560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)